CHRONIC INFLAMATION

My Health — Tue, 28 Apr 2009 17:02:08 +0000

Chronic Inflammation
Basic Features
prolonged, actively inflammed, tissue destruction, and attempts at healing Setting for chronic inflammation
persistent infections- granulomatous formation prolonged exposure to toxic agents
autoimmune diseases
Characterized by:
infiltration with mononuclear cells- macs, lymphs, and plasma cells
tissue destruction
angiogenesis and fibrogenesis Mononuclear infiltration major player is tissue macrophage
Mononuclear phagocyte system (RE system) monocytes begin to migrate early in acute inflammation, and are predominant cell type in 48 hours.

macs are activated by cytokines Products of these macrophages are involved in tissue injury and fibrosis
Three mechanisms of macrophage accumulation continued recruitment of monocytes from the circulation by continued expression of adhesion molecules and chemotactic factors C5a, IL-8, etc.
local proliferation of macrophages immobilization of macs at target site other cells involved include lymphs, plasma cells, eosinophils, and mast cells Fibrosis (repair by connective tissue) attempts at repair lead to scarring and fibrosis

Four components of process
angiogenesis migration and proliferation of fibroblastsdeposition of extracellular matrix remodeling
Granulation tissue is angiogenesis and fibrosis
Granulomatous inflammation
distinctive pattern of chronic inflammatory response in which the predominant cell type is an activated macrophage with a modified (epitheloid) appearance Granulomas are small round collections of macrophages surrounded by a rim of lymphocytes

Two types: Foreign body granulomas and immune granulomas
Granulomatous inflammation occurs with: TB, sarcoidosis, leprosy, cat scratch fever, schistosomiasis, syphilis, deep fungal diseases, inorganic metals and dusts Can be caseating or non-caseating Inability to digest inciting agent + CMI

Repair
Two distinct processes may be involved:
Regeneration- replacement of dead tissue by parenchymal cells of the same type
Replacement- connective tissue stroma (scar formation)
Chronology of the Repair process Removal of the inflammatory exudate 36 hrs to 3-4 weeks
begins with migration of macrophages Regeneration by parenchyma or fibrous proliferation type of replacement depends on the type of tissue injured begins within a few hours

Factors influencing the repair process
Types of cells
Labile cells- continue to multiply throughout life
Stabile cells- contain a latent capacity to regenerate, but under normal conditions do not undergo mitotic activity
Permanent Cells- no regenerative capacity (ex. cardiac myocytes and neurons)
Repair by connective tissue
Sequence of scar formation
fibroblasts and endothelial proliferation
begins as early as 24 hours and migration along fibrin strands begins within a few days
Collagen is detectable in 4 days increase in collagen leads to increased wound strength
progressive devascularization ( weeks to months )
Integration of Parenchymal and Connective Tissue Healing

Wound Healing
Healing by first intention (primary union)ideal healing occurs in a clean wound when the edges have been approximated Healing by second intention (secondary union)
extensive tissue loss dead tissue must be removed before healing can occur contraction of collagen after healing has occurred causes depression at the scar site
Stimulation of Cell Proliferation
No one knows how cell proliferation is initiated.

Wound Strength
Collagen is the ultimate source of strength of the healed wound Factors which modify the Inflammatory-Reparative Response age is not a factor A severe protein depletion impairs wound healing Vit C is important in formation of collagen hydrocortisones inhibit inflammatory reaction the better the blood supply, the more resistant to infection immobilization is important in healing of bone and excessive hemorrage

Post from: My Health HQ

CHRONIC INFLAMATION

inflammation

My Health — Mon, 27 Apr 2009 16:40:08 +0000

I had insane inflammation after toxin exposure. I was sent to all types of drs who tried to tell me I had arthritis (i didn’t), carpal tunnel (i didn’t), etc.
Inflammation is part of this illness – but it can be minimized much more effectively naturally, in my opinion and in my experience. Anti inflammatory pharma meds often have steroids in them – they caused me to swell up like a balloon. I felt horrible on them. I finally found an ND (licensed, Natural Dr – goes to med school but studies how to promote healing in the body, not how to medicate it with mainstream pharma) – they immediately put me on a gluten, sugar and dairy free diet – these things can naturally cause inflammation in the body. I removed stress from my life, another big inflammation cause. I got some herbal remedies that were specifically to help my body detoxify and balance. With detoxification (everything from mold, mercury, toxins in drinking water, etc) I have begun to heal. No pharma meds or surgery were needed. My thyroid, which was off the charts, has returned to the normal range. (My MD had NO IDEA how that happened without
synthroid, but my ND assured me that this happens all the time…MDs are simply not trained to heal people in the same way – they’re trained to give out medication, not seek the root cause for the issue.)
I am so thankful that I listened to my body and when they tried to pump meds down me and suggested surgery I said NO….we must search further to understand what is happening here.
I would encourage you, if you’re open to it, to seek advice from a qualified ND or Chinese Medicine Dr/herbalist. I’d imagine that you will be amazed by the results. I no longer have joint pain like I used to! I used to have a hard time standing up when I first got out of bed…now, I get up, no issues. I used to get stiff during the day – not a problem anymore.
Be well, good health to you.

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inflammation

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CHRONIC INFLAMATION

inflammation